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Detailed medicine guidance

Taking azithromycin with other medicines and herbal supplements

NHS medicines information on possible interactions with azithromycin and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Some medicines and azithromycin can affect each other.

Tell your doctor before you start azithromycin if you're taking any other medicines, including:

  • antacids for indigestion
  • ergotamine or dihydroergotamine – for migraine
  • medicines used to treat or prevent blood clots, such as warfarin, dabigatran, or edoxaban
  • hydroxychloroquine or chloroquine – medicines for rheumatoid arthritis and other inflammatory conditions
  • ciclosporin or tacrolimus – medicines to stop your immune system overreacting
  • colchicine, a medicine used for gout and some other inflammatory conditions
  • digoxin for some heart problems
  • rifabutin, an antibiotic
  • a statin medicine to lower your cholesterol, such as simvastatin or atorvastatin

Azithromycin can affect your heartbeat, so it's best not to take it with other medicines that have the same side effect.

Tell your doctor if you're taking medicines that can affect your heartbeat, including:

  • any medicines for an irregular heartbeat (arrhythmia), such as amiodarone or sotalol
  • antidepressants such as citalopram
  • antipsychotics used to treat mental health conditions
  • some anti-sickness medicines, such as domperidone
  • some antibiotics, such as moxifloxacin

These are not all the medicines that may cause problems if you take them with azithromycin. For a full list, see the leaflet inside your medicine packet. Talk to a pharmacist or your doctor if you're worried.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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