This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Cautions with other medicines
Some medicines and Buscopan can interact with each other and increase the chances of you having side effects.
Do not take Buscopan at the same time as some motion sickness medicines, such as domperidone or metoclopramide.
This is because they can stop each other from working. Metoclopramide and domperidone increase the movement of the gut, whereas Buscopan reduces it.
Some medicines increase the risk of side effects if you take them at the same time as Buscopan, including:
- medicines for allergies, such as antihistamines
- some medicines for depression, such as amitriptyline
- some medicines for mental health problems like schizophrenia or bipolar disorder, such as clozapine or chlorpromazine
- amantadine, a medicine for Parkinson's disease
- quinidine or disopyramide (heart medicines)
- some inhaled asthma medicines, including salbutamol, ipratropium and tiotropium
Do not take Buscopan together with other irritable bowel syndrome (IBS) remedies, as they work in the same way. You're unlikely to get extra relief for your symptoms, and it may cause more side effects. Take only 1 IBS remedy, unless your doctor tells you to take more than 1.
View the original NHS website page ↗. Refreshed 19 August 2026.
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