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Detailed medicine guidance

Taking or using ciprofloxacin with other medicines and herbal supplements

NHS medicines information on possible interactions with ciprofloxacin and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Some medicines can affect the way ciprofloxacin works. They can also make you more likely to get side effects.

It's important to tell your doctor if you take any of the following medicines before taking ciprofloxacin:

  • antacids for heartburn or indigestion – take ciprofloxacin at least 2 hours before antacids or at least 4 hours after
  • methotrexate, a medicine used to treat conditions such as rheumatoid arthritis
  • phenytoin, a medicine for epilepsy
  • steroids, such as prednisolone
  • theophylline or aminophylline for asthma
  • tizanidine, a medicine used for muscle stiffness
  • warfarin, a medicine to help prevent blood clots
Mixing ciprofloxacin with herbal remedies and supplements

Iron tablets (such as ferrous sulfate or ferrous fumarate), calcium and zinc supplements can affect ciprofloxacin. Leave 2 hours in between taking supplements and your dose of ciprofloxacin tablets or liquid.

There's not enough information to say whether other complementary medicines, herbal remedies and supplements are safe to take with ciprofloxacin. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Meds New IA (H2) - Cautions with other medicines alert

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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