This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Cautions with other medicines
Some medicines can affect how co-beneldopa works and may increase the chances of side effects.
Tell your doctor, specialist nurse or pharmacist if you're taking any other medicines, including:
- iron medicines or iron supplements
- tranylcypromine, phenelzine or isocarboxazid, for depression – also tell your doctor if you've taken any of these medicines within the last 2 weeks
- anti-sickness medicines, such as domperidone, metoclopramide or prochlorperazine
- antacids (used to treat indigestion)
- medicines for psychosis or schizophrenia, such as amisulpride, aripiprazole, haloperidol or risperidone
- medicines for high blood pressure, such as atenolol, ramipril or amlodipine
- medicines that make you sleepy, give you a dry mouth or make it difficult to pee (called anticholinergic side effects), including antihistamines, antidepressants and medicines for an overactive bladder
Many medicines have these anticholinergic effects, so check with a pharmacist if you're not sure. These medicines can affect how much co-beneldopa your body takes in and stop it from working properly.
These are not all the medicines that may cause problems if you take them with co-beneldopa. For a full list, see the leaflet inside your medicine packet.
Taking painkillers with co-beneldopa
It's usually OK to take mild painkillers, such as paracetamol and ibuprofen, if you need pain relief.
Check with your doctor before taking any stronger prescription painkillers, including opioids such as codeine, morphine or tramadol.
View the original NHS website page ↗. Refreshed 19 August 2026.
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