Taking eplerenone with other medicines and herbal supplements

Speak to your doctor or a pharmacist before starting eplerenone if you take any of the following:

• high blood pressure medicines like ramipril, enalapril, losartan or candesartan
• tacrolimus or ciclosporin, used to treat skin conditions such as psoriasis or eczema
• antibiotics, such as trimethoprim, clarithromycin, erythromycin or rifampicin
• medicines to treat HIV
• digoxin or amiodarone – used for heart conditions
• lithium – used to treat bipolar disorder
• painkillers such as diclofenac, ibuprofen, naproxen or aspirin
• medicines to treat fungal infections such as itraconazole or fluconazole
• medicines for epilepsy, such as phenytoin, carbamazepine or phenobarbital
• spironolactone or amiloride – medicines that affect your potassium levels
• warfarin – a medicine to prevent blood clots

St John's wort, a herbal medicine taken for depression, can affect how eplerenone works. Talk to your doctor if you're using it or planning to use it.

Do not take any potassium supplements, including salt substitute tablets. Taking these with eplerenone can cause your potassium levels to become too high. Some multivitamin and mineral supplements contain potassium. Always check the label.

There's not enough information to say that other complementary medicines, herbal remedies and supplements are safe to take with eplerenone. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.