Need emergency help? Call 999 in United Kingdom.

Open local help

Detailed medicine guidance

Taking flucloxacillin with other medicines and herbal supplements

NHS medicines information on possible interactions with flucloxacillin and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Some medicines can affect the way that flucloxacillin works and increase the chance of you having side effects.

Check with a pharmacist or your doctor if you're taking any other medicines, including:

  • methotrexate, an anti-inflammatory medicine for arthritis and similar conditions
  • warfarin, a medicine to prevent blood clots
  • medicines to treat gout including probenecid and sulfinpyrazone
  • voriconazole, a medicine used to treat fungal infections
  • other antibiotics

These are not all the medicines that may cause problems if you take them with flucloxacillin. For a full list, see the leaflet inside your medicine packet.

Important

Tell your doctor if you've recently had, or are due to have, an oral typhoid vaccination. Flucloxacillin can make it less effective.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

More about Flucloxacillin