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Detailed medicine guidance

Using lidocaine skin cream with other medicines and herbal supplements

NHS medicines information on possible interactions with lidocaine skin cream and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Lidocaine can sometimes affect the way other medicines work. However, this is more likely when you're using it at higher doses or if you're having lidocaine injections.

If you're following the leaflet instructions of your lidocaine skin cream or using it as your doctor or nurse tells you, it usually will not affect any other medicines.

Speak to your pharmacist if you have any questions.

Mixing lidocaine with herbal remedies and supplements

There's not enough information to say that complementary medicines, herbal remedies and supplements are safe to take with lidocaine. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Meds New IA (H2) - Cautions with other medicines alert

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

View the original NHS website page ↗. Refreshed 19 August 2026.

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