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Detailed medicine guidance

About loperamide

NHS medicines information on loperamide – what it's used for and key facts.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Loperamide is a medicine to treat diarrhoea (runny poo). It can help with short-term diarrhoea or irritable bowel syndrome (IBS).

Loperamide is also used for recurring or longer lasting diarrhoea from bowel conditions such as Crohn's disease, ulcerative colitis and short bowel syndrome.

Diarrhoea that starts suddenly usually gets better on its own within 5 to 7 days. If you need immediate short-term relief, taking loperamide can reduce the number of times you go to the toilet and it makes your poo less watery.

Loperamide works by slowing down food as it goes through your gut. Your body can then draw in more water from your intestines, so that your poos get firmer and you poo less often.

If you have a colostomy (where part of your bowel is brought through an opening made in your tummy, called a stoma) you may be prescribed loperamide. If you have a lot of poo and fluids coming through it, your stoma team may advise you to take high doses of loperamide to make your poo thicker and reduce the flow.

You can buy loperamide from pharmacies and shops. It's also available on prescription for treating some bowel conditions.

It comes as tablets, including tablets that dissolve on your tongue, and capsules. The tablets that dissolve are called Imodium Instants or Imodium Instant Melts.

Loperamide is also available combined with simeticone. Simeticone is used to treat farting (flatulence or wind). Taking these medicines together helps if you have diarrhoea with painful stomach cramps and bloating.

Loperamide mixed with simeticone is known by several brand names including Imodium Plus Caplets and Imodium Plus Comfort Tablets.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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