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Detailed medicine guidance

Taking loratadine with other medicines and herbal supplements

NHS medicines information on possible interactions with loratadine and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Some medicines affect how loratadine works or can increase the chances of you having side effects.

Tell your doctor if you're taking:

  • amiodarone, a medicine used to treat an irregular heartbeat
  • cimetidine, an indigestion medicine
  • erythromycin, an antibiotic
  • any medicine that makes you feel sleepy, gives you a dry mouth or makes it difficult for you to pee – taking loratadine might make these side effects worse

Taking it with painkillers

You can take loratadine together with painkillers such as paracetamol or ibuprofen.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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