This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Cautions with other medicines
Some medicines can affect the way medroxyprogesterone tablets work.
Tell your doctor if you're taking any of these medicines before starting to take medroxyprogesterone tablets:
- rifampicin, an antibiotic
- medicines to treat HIV or hepatitis C
- carbamazepine, phenytoin, phenobarbital (phenobarbitone) or primidone, medicines for epilepsy
- warfarin, a medicine to help prevent blood clots
Do not take St John's wort, a herbal remedy used for depression, with medroxyprogesterone. It can affect the way medroxyprogesterone works.
There's not enough information to say that other complementary medicines, herbal remedies and supplements are safe to take with medroxyprogesterone. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.
Meds New IA (H2) - Cautions with other medicines alert
Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.
View the original NHS website page ↗. Refreshed 19 August 2026.
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