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Side effects of methylphenidate for children

NHS medicines information on side effects of methylphenidate for children and what you can do to cope.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Common side effects of methylphenidate for children

These common side effects of methylphenidate may happen in more than 1 in 100 children. There are things you can do for your child to help them cope with them:

Headaches

Make sure your child rests and drinks plenty of fluids. Painkillers such as paracetamol (Calpol) can help.

Talk to your doctor if your child's headaches are severe or do not go away.

Trouble sleeping (insomnia)

If your child is finding it hard to sleep, try giving them their last dose at least 6 hours before bedtime. Speak to their doctor if this does not help. They may want to try slow release tablets or capsules instead.

Loss of appetite

It may help to give your child methylphenidate with a meal.

You may notice they lose some weight during the first few months of treatment. Your child will probably put this weight back on once they are used to the medicine.

If you notice they are losing a lot of weight speak to their doctor.

Stomach ache

Try to get your child to rest and relax. It can help if they eat and drink slowly and have smaller and more frequent meals. Putting a heat pad or covered hot water bottle on their stomach may also help.

If they're in a lot of pain, or it does not go away, speak to a pharmacist or their doctor.

Dry mouth

This usually gets better quite quickly. It may help to give your child small sips of water and citrus fruits like oranges or satsumas.

Feeling or being sick

Stick to simple meals and do not give your child rich or spicy food if they feel sick. It might help to give them their methylphenidate with or after a meal or snack.

If they're being sick, encourage them to take small, frequent sips of water or squash to avoid dehydration.

If your child keeps being sick or having severe stomach pains, see a doctor.

Keep giving your child the medicine, but tell your child's doctor if the advice on how to cope does not help and these side effects bother your child or do not go away.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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