Need emergency help? Call 999 in United Kingdom.

Open local help

Detailed medicine guidance

Taking or using metronidazole with other medicines and herbal supplements

NHS medicines information on possible interactions with metronidazole and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Metronidazole may not mix well with some other medicines. This can be a problem with metronidazole tablets, suppositories, liquid or vaginal gel. It is not usually a problem if you are using a skin gel or cream, as only a small amount of metronidazole is absorbed into the body.

Check with a pharmacist or your doctor if you're taking any other medicines, including:

  • warfarin, a medicine that helps to treat and prevent blood clots
  • lithium, used to treat some types of mental health conditions
  • disulfiram, used to help people stay off alcohol
  • phenytoin or phenobarbitone, used to treat epilepsy
  • ciclosporin, used to reduce the activity of the immune system
  • fluorouracil or busulfan, used to treat some types of cancer
  • any medicines that you take as a liquid, in case these contain alcohol

These are not all the medicines that may cause problems if you take them with metronidazole. For a full list, see the leaflet inside your medicine packet.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

More about Metronidazole