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Detailed medicine guidance

Taking montelukast with other medicines and herbal supplements

NHS medicines information on possible interactions with montelukast and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

There are some medicines that may affect how montelukast works.

Tell your doctor or pharmacist if you're taking any of these medicines:

  • epilepsy medicines such as phenobarbital or phenytoin
  • rifampicin, for tuberculosis and some other infections
  • gemfibrozil, for high cholesterol

It's usually safe to take everyday painkillers with montelukast. However, do not take non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen if they've ever made your asthma symptoms worse.

Mixing montelukast with herbal remedies and supplements

There's not enough information to say that complementary medicines and herbal remedies are safe to take with montelukast. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Meds New IA (H2) - Cautions with other medicines alert

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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