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Detailed medicine guidance

Taking prednisolone with other medicines and herbal supplements

NHS medicines information on possible interactions with prednisolone and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

There are many medicines that can affect the way prednisolone works, or increase the risk of side effects. It's very important you check a medicine is safe to take with prednisolone before you start taking it.

This includes anti-inflammatory painkillers such as ibuprofen and aspirin.

Mixing prednisolone with herbal remedies or supplements

There's very little information about taking herbal remedies and supplements with prednisolone.

It's not possible to say that herbal remedies and supplements are safe to take with prednisolone. They're not tested in the same way as pharmacy and prescription medicines.

Meds New IA (H2) - Cautions with other medicines alert

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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