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Detailed medicine guidance

Taking ramipril with other medicines and herbal supplements

NHS medicines information on possible interactions with ramipril and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

There are some medicines that may affect the way ramipril works, including medicines that affect your kidneys, blood pressure or how much potassium is in your blood.

Tell your doctor if you're taking any of these medicines:

  • NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen, indometacin or aspirin for pain relief (daily low-dose aspirin of 75mg is safe to take with ramipril)
  • medicines that can increase the amount of potassium in your blood, such as spironolactone, triamterene, amiloride, potassium
  • medicines to treat low blood pressure, heart failure, asthma or allergies, such as ephedrine, noradrenaline or adrenaline
  • medicines for high blood pressure, such as aliskeren
  • medicines that increase the risk of angioedema such as sacubitril, valsartan, racecadotril, sirolimus, tacrolimus, everolimus and vildagliptin
  • medicines that can lower your blood pressure, such as some antidepressants, nitrates (for chest pain), baclofen (a muscle relaxant), anaesthetics or medicines for an enlarged prostate gland
  • medicines to calm down your immune system, such as ciclosporin or tacrolimus
  • medicines that make you pee more (diuretics), such as furosemide,  trimethoprim (for infections) or heparin (for preventing blood clots)
  • steroid medicines such as prednisolone
  • allopurinol, for gout
  • procainamide, for heart rhythm problems
  • medicines for diabetes
  • lithium, for mental health problems

These are not all the medicines that may cause problems if you take them with ramipril. For a full list, see the leaflet inside your medicine packet.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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