This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Common side effects
Common side effects of senna, which happen in more than 1 in 100 people, are stomach cramps and diarrhoea.
You are particularly likely to get stomach cramps and diarrhoea with senna if you have constipation related to irritable bowel syndrome (IBS).
Stop taking senna if you get diarrhoea.
If you take the combined contraceptive pill or progestogen-only pill and you have severe diarrhoea for more than 24 hours , your contraception may not protect you from pregnancy. Check the pill packet for advice.
Your pee may turn a red-brown colour while you’re taking senna. This is harmless and returns to normal after treatment has ended.
Talk to your doctor or pharmacist if the side effects bother you or do not go away.
Serious allergic reactionIn rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to senna.
Meds New IA (H4) - serious allergic reaction
Call 999 now if:
- your lips, mouth, throat or tongue suddenly become swollen
- you're breathing very fast or struggling to breathe (you may become very wheezy or feel like you're choking or gasping for air)
- your throat feels tight or you're struggling to swallow
- your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- you suddenly become very confused, drowsy or dizzy
- someone faints and cannot be woken up
- a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)
You or the person who's unwell may also have a rash that's swollen, raised, itchy, blistered or peeling.
These can be signs of a serious allergic reaction and may need immediate treatment in hospital.
Long-term side effects
Ideally you'll only take senna for a few days. Taking it for a long time can cause an electrolyte imbalance, where levels of substances like sodium, potassium and magnesium in your body get too high or too low.
A severe electrolyte imbalance can cause serious health problems, such as muscle spasms or twitching, and even cause a seizure or fit.
Using senna for many weeks, even months, could also stop your bowel working properly on its own.
Only take senna regularly long term if it has been prescribed for you.
Other side effectsThese are not all the side effects of senna. For a full list see the leaflet inside your medicines packet.
View the original NHS website page ↗. Refreshed 19 August 2026.
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