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Detailed medicine guidance

Taking tolterodine with other medicines and herbal supplements

NHS medicines information on possible interactions with tolterodine and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Some medicines and tolterodine can affect each other. This can increase the chance of side effects.

Tell your doctor if you're taking any other medicines, including:

  • antibiotics like erythromycin or clarithromycin
  • itraconazole or fluconazole, which are used to treat fungal infections
  • medicines used to treat HIV
  • anti-sickness medicines like metoclopramide, prochlorperazine or domperidone
  • amiodarone, sotalol, quinidine or procainamide, which are used to treat irregular heartbeats
  • other medicines that work in a similar way to tolterodine, such as fesoterodine
  • any medicines used to treat irritable bowel syndrome, asthma, incontinence, motion sickness or movement disorders related to Parkinson's disease, that work in a similar way to tolterodine
  • phenothiazines, clozapine, haloperidol or benperidol, medicines for mental health problems
  • donepezil, rivastigmine, galantamine or tacrine, medicines used for dementia
  • medicines for depression such as amitriptyline, imipramine or dosulepin (tricyclic antidepressants)
  • medicines used to make you feel sleepy (sedatives)

These are not all the medicines that may cause problems if you take them with tolterodine. For a full list, see the leaflet inside your medicine packet.

Taking tolterodine with painkillers

It's safe to take tolterodine with everyday painkillers like paracetamol.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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