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Detailed medicine guidance

Who can and cannot take varenicline

NHS medicines information on who can take varenicline and who may not be able to take it.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Who can take varenicline

Most adults can take varenicline.

Who may not be able to take varenicline

Varenicline is not suitable for some people. To make sure it’s safe for you, tell your doctor before starting to take varenicline if you:

  • have ever had an allergic reaction to varenicline or any of the ingredients in it
  • have kidney problems
  • have ever had problems with your heart
  • are pregnant or breastfeeding
  • have ever had a seizure or fit

Varenicline can also cause or make some conditions worse. These include:

  • depression and other mental health conditions
  • sleep problems such as insomnia
  • abnormal dreams

This is not common but talk to a doctor before taking varenicline.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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