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Detailed medicine guidance

Using fentanyl with other medicines and herbal supplements

NHS medicines information on possible interactions with fentanyl and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

There are some medicines that may affect how fentanyl works and increase the chance that you'll have side effects.

Tell your doctor if you're taking any medicines:

  • to help you sleep
  • for high blood pressure
  • for an irregular heartbeat
  • to help stop you feeling or being sick
  • to treat symptoms of an allergy
  • for mental health problems including depression, or to reduce stress or anxiety
  • for any infection (including HIV)
  • to control fits or seizures
Taking fentanyl with other painkillers

It's safe to take fentanyl with paracetamol, ibuprofen or aspirin.

Do not take any painkillers containing codeine including co-codamol, ibuprofen and codeine (Nurofen Plus) or Solpadeine when using fentanyl. You'll be more likely to get side effects if you take any of these while using fentanyl.

Mixing fentanyl with herbal remedies and supplements

There's not enough information to say that complementary medicines and herbal remedies are safe to take with fentanyl. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Meds New IA (H2) - Cautions with other medicines alert

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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