This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.
Cautions with other medicines
Some medicines and lansoprazole can affect each other and make you more likely to have side effects or stop one of the medicines working as well.
Antacids can reduce the amount of lansoprazole that the body takes in so it does not work as well. To stop this happening, if you need to take an antacid, take it at least 2 hours before or after your dose of lansoprazole.
Tell your doctor before you start taking lansoprazole if you're taking any other medicines including:
- digoxin, a heart medicine
- antifungal medicines such as itraconazole or posaconazole
- methotrexate, a medicine that treats psoriasis and rheumatoid arthritis
- HIV medicines
- rifampicin, an antibiotic
- warfarin, to prevent or treat blood clots
- fluvoxamine, an antidepressant
- tacrolimus, to treat eczema or after an organ transplant
These are not all the medicines that may not mix well with lansoprazole. For a full list see the leaflet inside your medicines packet.
View the original NHS website page ↗. Refreshed 19 August 2026.
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