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Detailed medicine guidance

Taking prochlorperazine with other medicines and herbal supplements

NHS medicines information on possible interactions with prochlorperazine and other medicines, herbal remedies and supplements.

About this information

This NHS content is written for people in England. Medicine names, availability, prescribing and services may differ in other countries.

Cautions with other medicines

Some medicines and prochlorperazine do not work well together. This can increase the chance of having side effects.

Tell your pharmacist or doctor if you're taking any medicine that:

  • makes you sleepy or drowsy
  • gives you a dry mouth
  • can affect your heart

Taking prochlorperazine might make these side effects worse.

Taking it with other anti-sickness medicines

It's usually best to only take 1 type of medicine for feeling or being sick.

If prochlorperazine does not work for you, speak to your doctor and they may suggest a different medicine.

Mixing prochlorperazine with herbal remedies or supplements

Some herbal remedies can make your side effects worse.

There's not enough information to say that complementary medicines, herbal remedies and supplements are safe to take with prochlorperazine. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Meds New IA (H2) - Cautions with other medicines alert

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

View the original NHS website page ↗. Refreshed 19 August 2026.

Licensed under the Open Government Licence v3.0 ↗. MyPHU is independent and is not endorsed by the NHS.

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